organ on a chip

Implementing an organ-on-a-chip into your experimental paradigm

An organ-on-a-chip is produced by an organ on a chip company and constitutes a more or less successful substitute of an organ or organ system. That is, an organ-on-a-chip is used to model what kind of reaction an organ or organ system would have to a possible outside influence. You can think of the following, for instance:

–          Temperature changes

–          Neurotransmitters

–          Hormones

When an organ on a chip company manages to create a fruitful model, it can be used to in vitro mimic a real life situation. In research, this can be an indispensable opportunity. Therefore, an organ-on-a-chip is highly sought after in these communities.

The moral advantages of an organ-on-a-chip

When drug development started out in the medical sciences and there were no instances of an organ on a chip company yet, animals models constituted the sole way of obtaining in vivo data about possible human responses to drug trials. Animal trials have been shunned however, for instance on the basis of moral objections, but animal trials are also expensive and lengthy. Therefore, an organ-on-a-chip alternative was deemed necessary.

An alternative that was necessary

An organ-on-a-chip company caused in vitro models to be less expensive. Animals could now be replaced by testing in vitro, i.e. by using an organ-on-a-chip produced by an organ on a chip company. That is, when a certain chip can mimic a certain organ or organ system of humans as well as a live animal, then it is both morally and economically valid to choose for the production of an apparatus. The model can additionally be used over and over again and influenced more easily by means of programming. All in all, the development of the aforementioned apparatus caused a profound change in research.

http://www.micronit.com/blog/portfolio-item/organ-on-a-chip/